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trk b inhibitor  (LKT Laboratories)


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    Structured Review

    LKT Laboratories trk b inhibitor
    Trk B Inhibitor, supplied by LKT Laboratories, used in various techniques. Bioz Stars score: 85/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/trk+b+inhibitor/K252a/pmc03578719-38-6-9
    Average 85 stars, based on 6 article reviews
    trk b inhibitor - by Bioz Stars, 2026-09
    85/100 stars

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    Related Articles

    other:

    Article Title: Activation of Different Signals Identified with Glia Cells Contribute to the Progression of Hyperalgesia
    Article Snippet: K252a group: 50 μg/10 μL of Trk-B inhibitor (K252a; LKT Laboratories Inc., Saint Paul, USA).



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    Effect of <t>ANA-12</t> treatment on sensory neurons’ excitability in BO. Sham and BO rats were treated without or with Trk B inhibitor ANA-12 (1 mg/kg in 200 microliter 10% DMSO, i.p.) once a day on day 2, 4, and 6. Rats were euthanized on day 7 for DRG neuron isolation and patch clamp. N = 20~31 neurons in each group (4 or 5 rats). * p<0.05 vs sham. # p<0.05 vs BO.
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    Image Search Results


    Effect of ANA-12 treatment on sensory neurons’ excitability in BO. Sham and BO rats were treated without or with Trk B inhibitor ANA-12 (1 mg/kg in 200 microliter 10% DMSO, i.p.) once a day on day 2, 4, and 6. Rats were euthanized on day 7 for DRG neuron isolation and patch clamp. N = 20~31 neurons in each group (4 or 5 rats). * p<0.05 vs sham. # p<0.05 vs BO.

    Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

    Article Title: Role of brain-derived neurotrophic factor in the pathogenesis of distention-associated abdominal pain in bowel obstruction

    doi: 10.1111/nmo.13373

    Figure Lengend Snippet: Effect of ANA-12 treatment on sensory neurons’ excitability in BO. Sham and BO rats were treated without or with Trk B inhibitor ANA-12 (1 mg/kg in 200 microliter 10% DMSO, i.p.) once a day on day 2, 4, and 6. Rats were euthanized on day 7 for DRG neuron isolation and patch clamp. N = 20~31 neurons in each group (4 or 5 rats). * p<0.05 vs sham. # p<0.05 vs BO.

    Article Snippet: In some in vivo experiments, specific Trk B inhibitor ANA-12 (1 mg/kg in 200 microliter 10% DMSO, i.p.) (Sigma-Aldrich, St. Louis, MO] [ 36 , 37 ] was administered to sham and BO rats once a day on day 2, 4, and 6.

    Techniques: Isolation, Patch Clamp

    Effect of ANA-12 administration on Kv activity (panel A) and on withdrawal response (B and C) in sham and BO rats. Rats were euthanized on day 7 for DRG neuron isolation for patch clamp recording of Kv activity. ANA-12 treatment prevented reduction of total Kv and IA activity. N = 20~31 neurons (4 or 5 rats) in each group. * p<0.05 vs sham. # p<0.05 vs BO. The VFF test showed that the referred sensitivity to mechanical stimulation to abdominal wall was significantly increased in BO (day 7) (B). However, ANA-12 treatment partially attenuated obstruction-associated refereed hypersensitivity (C). N= 6 rats in each group. *p < 0.05 vs. sham control of the group.

    Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

    Article Title: Role of brain-derived neurotrophic factor in the pathogenesis of distention-associated abdominal pain in bowel obstruction

    doi: 10.1111/nmo.13373

    Figure Lengend Snippet: Effect of ANA-12 administration on Kv activity (panel A) and on withdrawal response (B and C) in sham and BO rats. Rats were euthanized on day 7 for DRG neuron isolation for patch clamp recording of Kv activity. ANA-12 treatment prevented reduction of total Kv and IA activity. N = 20~31 neurons (4 or 5 rats) in each group. * p<0.05 vs sham. # p<0.05 vs BO. The VFF test showed that the referred sensitivity to mechanical stimulation to abdominal wall was significantly increased in BO (day 7) (B). However, ANA-12 treatment partially attenuated obstruction-associated refereed hypersensitivity (C). N= 6 rats in each group. *p < 0.05 vs. sham control of the group.

    Article Snippet: In some in vivo experiments, specific Trk B inhibitor ANA-12 (1 mg/kg in 200 microliter 10% DMSO, i.p.) (Sigma-Aldrich, St. Louis, MO] [ 36 , 37 ] was administered to sham and BO rats once a day on day 2, 4, and 6.

    Techniques: Activity Assay, Isolation, Patch Clamp